Isa Ali Abdullah al Murbati, Guantanamo Bay detainee
Issa Hentona, lead singer of J-pop band Da Pump
Issa Lish, Mexican model
Issa Sesay, a military leader in the Sierra Leone insurgency
Issa, the nickname of Luttif Afif, a leader of the Black September terror squad at the 1972 Olympic Games
Issa, a divine character in David Eddings's fantasy series The Belgariad and The Malloreon
Issa Diop, Issa (Senegalese singer), singer, songwriter, and record producer
Issa, the identity which Canadian musician Jane Siberry took upon changing her name
Darrell Issa, a Californian Representative
Kobayashi Issa, Japanese haiku poet
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Irshya (Sanskrit, also īrṣyā; Pali: issā; Tibetan: phrag dog) is a Buddhist term that is translated as "jealousy" or "envy". It is defined as a state of mind in which one is highly agitated to obtain wealth and honor for oneself, but unable to bear the excellence of others.