Increase in serum uric acid is seen idiopathically and in renal failure, disseminated neoplasms, toxemia of pregnancy, psoriasis, liver disease, sarcoidosis, ethanol consumption, etc. Many drugs elevate uric acid, including most diuretics, catacholamines, ethambutol, pyrazinamide, salicylates, and large doses of nicotinic acid. Decreased serum uric acid level may not be of clinical significance. It has been reported in Wilson's disease, Fanconi's syndrome, xanthinuria, and (paradoxically) in some neoplasms, including Hodgkin's disease, myeloma, and bronchogenic carcinoma. Uric acid is formed in the breakdown of nucleoproteins in the tissues, and excreted in the urine. It is found in the bloodstream within a normal range (2 - 8 milligrams per deciliter). Elevated blood uric acid levels can put patients at an increased risk for kidney stone formation
Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C5H4N4O3. It forms ions and salts known as urates and acid urates, such as ammonium acid urate. Uric acid is a product of the metabolic breakdown of purine nucleotides. High blood concentrations of uric acid can lead to gout and are associated with other medical conditions including diabetes and the formation of ammonium acid urate kidney stones.
Copyright: Aegis Dictionary source: Aids Glossary
English to English translation of uric acid
A breakdown product of purines that are part of many foods. In gout, there are frequently, but not always, elevated levels of uric acid in the blood (hyperuricemia). However, only a small portion of those with hyperuricemia will develop gout.